Maria Anna was very weak but her fathers absolute favorite because of her interests in science. She was known in her family as "Marianne" but because of her weak condition she was unable to marry. She never married or had any issue.
- Maria Anna, or Marianne, was actually the second born child to Frans Joseph and Maria Theresia but her elder sister died at age 3 when Marianne was barely a year old, leaving her the eldest child.
- She died in the year of the french revolution, which famously caused the death of her youngest sister.